Computational and Biochemical Approaches to Molecular Epidemiology
Michael Calhoun; Hannah Dysinger; David Hobbs, Ph.D.; and Katie Hailer, Ph.D.
Mining activity in Butte, Montana has taken place, or continues to take place, within the urban residence of Butte itself. This has led to urban areas with high concentrations of toxic metals such as arsenic, lead, copper, zinc, mercury and cadmium. Advances in protein study and gene sequencing has opened the possibility of finding molecular biomarkers whose presence, absence or morphological changes could indicate disease processes in populations exposed to environmental toxins. While in principle, biomarkers can be any chemicals or metabolites, as well as proteins and genes that are indicative of exposure to xenobiotics, this study seeks to identify changes in cellular pathways that suggest chronic (or acute) exposure to low-levels of metals associated with historical mining activities on the Butte Hill that could cause oxidative stress or other stress to the cell.
Parental Abuse, Risky Behavior and Psychopathic Traits in Adolescents and Early Adults
M P. Chorney; J M. Reistad; and Scott Risser, Ph.D.
This study examines the associations between parental abuse, risky behavior, and affective psychopathic traits. Ninety-one (49% males) rural adolescents and young adults (between the ages of fourteen and twenty-five) participated in an investigation of gene and environment interactions. The sample consisted of high school and undergraduate college students. These participants provided self-reports of parental abuse, risky behaviors, and psychopathic affective traits. Results suggested that psychopathic traits, especially a lack of remorse and parental abuse, independently account for some risky behavior.
Wetting and Reactive Air Brazing of BSCF for Oxygen Separation Devices
Richard LaDouceur and Alan Meier, Ph.D.
The goals of this project are to develop a Reactive Air Brazing (RAB) alloy and process for joining Barium strontium cobalt ferrite (BSCF), and to develop a fundamental understanding of the wettability and microstructral development due to reaction kinetics in BSCF/Ag-MexOy systems.
Organic Wastewater Chemicals in Silver Bow Creek - Butte to Warm Springs Ponds
Heidi Reid; Katie Hailer, Ph.D.; and Steve Parker, Ph.D.
The purpose of this study is to detail and analyze the distribution, concentration, and loads of 5 organic compounds along Silver Bow Creek in Butte, Montana from the Municipal Wastewater treatment plant to the Warm Springs Ponds. The chemicals analyzed include Carbamazepine (pharmaceutical), Miconazole (fungicide) and three antibiotics – Sulfamethoxazole, Thiabendazole, and Ciprofloxacin.
This project begins a 2 year study to analyze 6 additional compounds (11 compounds total), to develop an effective method to detail and analyze OWCs using Mass Spectrometer/Liquid chromatography system, and to aid in assessment of aquatic health and ongoing restoration work. The EPA method 1694 was used for analysis
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