Closing the gate: Restrictions to neuroinvasive HSV-1 spread
The Taylor Lab is interested in the intercellular spread of neuroinvasive viruses and how spread impacts viral evolution and pathogenesis. Neuroinvasive viruses have the capacity to infect the cells of the nervous system, transmitting viral particles (virions) between neurons. Using the connections between neurons, the infection invades the central nervous system resulting in severe disease and death. The main focus is the neuroinvasive alphaherpes viruses which include the human pathogen Herpes Simplex virus type 1 (HSV-1) and the porcine pathogen Pseudorabies virus (PRV). Our research has centered on the host and viral factors that restrict or otherwise regulate the spread of infection between neurons. Through this work, we will identify the most impactful mechanisms to regulate viral disease in the nervous system.
Taylor, Matt, "Closing the gate: Restrictions to neuroinvasive HSV-1 spread" (2019). Public Lecture Series. 151.