Thixotropic Hydrogels for Biomedical Applications

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Tetraethyl orthosilicate (TEOS)-based systems are thixotropic (gel-like) under static conditions and solution-like under agitation or sheer. They can be understood as dynamically crosslinked systems that assemble and disassemble via electrostatic interactions. This versatility supports applications, including: a thixotropic antibacterial releasing system that could become a veterinary otic therapeutic; and (2) a cell-compatible, reversible three-dimensional culture system with high throughput capabilities.

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Dr. Monica Serban joined the University of Montana-Missoula as an assistant professor in 2015. She has 5 years of industry experience: first with Tengion, a develop-ment-stage regenerative medicine company, then moving to Allergan Medical’s Product Development team. Her re-search involves translational projects for diverse biomedical applications. Monica’s 2007 Ph.D. is in medicinal chemistry.